Description:horse chestnut is a plant. its seed, bark, flower, and leaves are used to make medicineindication:varicose veins and other circulatory problems (chronic venous insufficiency). taking horse chestnut seed extract can reduce some symptoms of poor blood circulation, such as varicose veins, pain, tiredness, swelling in the legs, itching, and water retention.dose:for poor blood circulation (chronic venous insufficiency): 300 mg of horse chestnut seed extract containing 50 mg of the active ingredient, aescin, twice daily.interaction:medications for diabetes (antidiabetes drugs) interacts with horse chestnuthorse chestnut might decrease blood sugar. diabetes medications are also used to lower blood sugar. taking horse chestnut along with diabetes medications might cause your blood sugar to go too low.