Description : amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. recurrent aphthous ulcer (rau) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population.indication :used as a paste in the mouth to treat aphthous ulcersmechanism of action :amlexanox has anti-inflammatory and antiallergic properties. it inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (srs-a) and may have antagonistic effects on interleukin-3. when cells are under stress, they release an inactive form of human fibroblast growth factor 1 (fgf-1), a potent mitogen (entity that causes mitosis). amlexanox binds to fgf1, increasing its conformational stability, sterically blocking cu(2+) induced oxidation which normally leads to activation of fgf-1.