About fluconazolea triazole derivative, a board range antifungal.mechanism of action of fluconazolefluconazole is fungicidal or fungistatic depending on the drug concentrations. i t inhibits the conversion of lanosterol to 14 demethyl lanosterol by inhibiting the cytochromep450 enzyme 14 alpha demethylase and impair ergosterol synthesisinteractions for fluconazolecimetidine: decreased efficacy of fluconazole. cyclosporine: increase in serum cyclosporine plasma concentration. hydrochlorothiazide: reduction in renal clearance of fluconazole. phenytoin: efficacy of phenytoin enhanced. rifampicin: efficacy of fluconazole decreased, higher dosage required. sulfonylureas: efficacy of tolbutamide, glyburide and glipizide increased. warfarin: potentiates the anticoagulant effect resulting in increase in prothrombin time. indications for fluconazole1.oesophageal candidiasis 2.oropharyngeal candidiasis 3.vaginal candidiasis 4.systemic candidiasis 5.cryptoc