Viscum fraxini 2, mistletoe extract, stimulates the t and b-cell components of the immune system, which leads to the expression and release of cytokines, proliferation and activation of immuno-competent cells- especially natural killer cells, t-cytotoxic cells and lymphokine activated killer cells.treatment with viscum fraxini 2 is associated with an improvement of the quality of life of cancer patients.viscum fraxini 2 stimulates the secretion of endogenous ?-endorphins which leads to the control of pain.viscum fraxini 2 contains lectins which enhance apoptosis and viscotoxins which exert direct cytotoxic effect on tumor cells.*indications:-pleurodesis in malignant pleural effusion.-supportive for inoperable hepatocellular carcinoma patients.-complementary in breast cancer. dosage:*dose in malignant pleural effusion:5 ampoules of viscum fraxini 2 mixed with 10 ml of glucose 5% intrapleural weekly till complete pleurodesis or up to six weeks.