About xylometazolineimidazoline derivative,alpha-2 adrenergic agonist, topical nasal decongestant.mechanism of action of xylometazolineit is a nasal decongestant with selective alpha-2 agonistic action. it produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion.indications for xylometazoline1. nasal congestionsinteractions for xylometazolinetricyclic antidepressants: xylometazoline may potentiate the pressor effects of tricyclic antidepressants.