About domperidonesantidopaminergic, motility stimulant,piperidine derivative, antiemetic, anti-vertigo.smechanism of action of domperidonesdomperidone is a potent dopamine receptor antagonist. it acts centrally and blocks the dopamine receptor in the chemoreceptor trigger zone and produces antiemetic effect. sdomperidone acts peripherally in the gastrointestinal system and increases oesophageal peristalsis, oesophageal sphincter pressure and gastric motility. these all facilitates gastric emptying. domperidone is used in migraine to relieve nausea and vomiting. sanaesthetic adjuncts: it is used preoperatively in order to reduce the post operative vomiting. ssindications for domperidones1.nausea and vomiting associated with gastrointestinal disorder and migraine. s2.delayed gastric emptying of functional origin s3.as an antiemetic in patient receiving cytotoxic drugs s4.preanaesthetic medication