About cefuroximesecond generation cephalosporin antibiotic.mechanism of action of cefuroximecefuroxime is a 2nd generation cephalosporin which exerts its bactericidal action against both gram positive & gram negative organisms by inhibiting bacterial cell wall synthesis. cefuroxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like cefuroxime indications for cefuroxime1.meningitis caused by h.influenzae, meningococci, pneumococci etc. 2.gonorrhea 3.pneumonia & pulmonary infections 4.infections caused by ampicillin resistant h. influenzae 5.septicemia 6.tonsillitis 7.pharyngitis 8.urinary tract infections 9.otitis media