Amoxicillin is an analog of ampicillin derived from the basic penicillin nucleus 6-aminopenicillanic acid
clavulanic acid is produced by the fermentation of streptomyces clavuligerus. it is a beta-lactam structurally related to the penicillins and possesses the ability to inactivate some beta-lactamases by blocking the active sites of these enzymes.
lower respiratory tract infections – caused by beta-lactamase–producing isolates of haemophilus influenzae and moraxella catarrhalis.

acute bacterial otitis media – caused by beta-lactamase–producing isolates of h. influenzae and m. catarrhalis.

sinusitis – caused by beta-lactamase–producing isolates of h. influenzae and m. catarrhalis.

skin and skin structure infections – caused by beta-lactamase–producing isolates of staphylococcus aureus escherichia coli and klebsiella species.

urinary tract infections – caused by beta-lactamase–producing isolates of e. coli klebsiella species and enterobacter species.
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