Etoricoxib is indicated for the treatment of rheumatoid arthritis psoriatic arthritis osteoarthritis ankylosing spondylitis chronic low back pain acute pain and gout.

like any other selective cox-2 inhibitor ("coxib") etoricoxib selectively inhibits isoform 2 of the enzyme cyclooxygenase (cox-2). it has approximately 106-fold selectivity for cox-2 inhibition over cox-1.