Severe hypertriglyceridemia

indicated as an adjunct to diet to reduce high triglyceride levels (ie =500 mg/dl)

mechanism of action

ethyl ester of eicosapentaenoic acid (epa); epa has been shown to reduce hepatic very low-density lipoprotein triglycerides (vldl-tg) synthesis and/or secretion; enhances triglyceride clearance from circulating vldl particle; may also increase beta-oxidation inhibits acyl-coa:1 2-diacylglycerol acyltransferase (dgat) decrease lipogenesis in liver and increase plasma lipoprotein lipase activity.