About fluconazole
a triazole derivative a board range antifungal.

mechanism of action of fluconazole
fluconazole is fungicidal or fungistatic depending on the drug concentrations. i t inhibits the conversion of lanosterol to 14 demethyl lanosterol by inhibiting the cytochromep450 enzyme 14 alpha demethylase and impair ergosterol synthesis

interactions for fluconazole
cimetidine: decreased efficacy of fluconazole.
cyclosporine: increase in serum cyclosporine plasma concentration.
hydrochlorothiazide: reduction in renal clearance of fluconazole.
phenytoin: efficacy of phenytoin enhanced.
rifampicin: efficacy of fluconazole decreased higher dosage required.
sulfonylureas: efficacy of tolbutamide glyburide and glipizide increased.
warfarin: potentiates the anticoagulant effect resulting in increase in prothrombin time.

indications for fluconazole
1.oesophageal candidiasis
2.oropharyngeal candidiasis
3.vaginal candidiasis
4.systemic candidiasis
5.cryptoc