About duloxetine
a serotonin-norepinephrine reuptake inhibitor thiophene derivative antidepressant.

mechanism of action of duloxetine
duloxetine preferentially inhibits the re-uptake of noradrenaline and serotonin (5 ht) in the cns nerve terminals .this will result in an increased concentration of neurotransmitter serotonin in the synaptic cleft and produces antidepressant effect

indications for duloxetine
1. major depressive disorder
2. diabetic peripheral neuropathic pain
3. generalised anxiety disorder

typical dosage for duloxetine
major depressive disorder: 20 - 60mg / day in 2 divided doses
diabetic peripheral neuropathic pain:60 mg/day
generalized anxiety disorder: 60 mg/ day