About chlorpromazine
aliphatic phenothiazine derivative first-generation antipsychotic(typical) anticholinergic antidopaminergic antihistaminic and antiadrenergic tranquilizer antiemetic
mechanism of action of chlorpromazine
antipsychotic action: chlorpromazine binds to the dopamine receptor (d1 d2 d3 &d4).it exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. peripherally and centrally it acts as a competitive dopamine antagonist. chlorpromazine also produces alpha adrenergic blocking activity and anticholinergic activity. it also produces weak h1 antihistaminic activity and anti serotonin activity.
antiemetic action: chlorpromazine exerts its antiemetic action by blocking the dopamine receptor in the medullary chemoreceptor trigger zone.
antimigraine action: chlorpromazine has been used in migraine to control severe nausea and vomiting unresponsive to antiemetics and to relieve the pain of severe migrai