Therapeutic indicationsreduction of intraocular pressure (iop) in adult patients with open angle glaucoma or ocular hypertension who are insufficiently responsive to topical monotherapy with beta-blockers or prostaglandin analogues and require a combination therapy, and who would benefit from preservative free eye drops.recommended therapy is one eye drop in the conjunctival sac of the affected eye(s) once daily.tafluprost is a fluorinated analogue of prostaglandin f2alpha.timolol maleate is a non-selective beta-adrenergic receptor blocking agent.