Immunate is a coagulation factor viii / von willebrand factor complex made from human plasma. the coagulation factor viii in immunate replaces the factor viii which is lacking or is not functioning properly in haemophilia a. haemophilia a is a sexlinked, hereditary blood coagulation defect due to reduced factor viii levels. this results in severe bleeding in joints, muscles and inner organs, either spontaneously or as a consequence of accidental or surgical traumata. the administration of immunatetemporarily corrects the factor viii deficiency and reduces the bleeding tendency.in addition to its role as a factor viii protecting protein, von willebrand factor (vwf) mediates platelet adhesion to sites of vascular injury and plays a role in platelet aggregation.immunate is used for the treatment and prevention of bleeding in congenital (haemophilia a) or acquired factor viii deficiency.immunate is also used in von willebrand’s disease with factor viii deficiency.