Pharmacologymethylfolate, or l-methylfolate, is the active form of folate in the body, which can be transported into peripheral tissues and across the blood-brain barrier. folate is necessary for formation of numerous coenzymes in many metabolic systems, particularly for purine, pyrimidine, and nucleoprotein synthesis, and maintenance in erythropoiesis- stimulates wbc and platelet production in folate deficiency anemia.indicationsmedical food for the nutritional requirements of patients with suboptimal l-methylfolate and who have major depressive disorder or schizophrenia.