About fludarabineantimetabolite (purine antagonist), organofluoride derivative, antineoplastic. mechanism of action of fludarabineintracellularly drug is converted into its active form 2-flouro-ara-atp by the enzyme deoxycytidine kinase through dephosphorylation and phosphorylation steps. this active metabolite inhibits the enzymatic action of dna polymerase alpha, ribonucleotide reductase and dna primase. it causes the dna synthesis inhibition and death of cancer cells.it also inhibits the dna synthesis of resting cells.indications for fludarabine1. b-cell chronic lymphocytic leukemia who have not responded to or whose disease has progressed during treatment with at least one standard alkylating agent containing regimen 2. chronic lymphocytic leukemia 3. hodgkins disease 4. malignant lymphoma 5. hairy-cell leukemia 6. mycosis fungoides interactions for fludarabinepentostatin (deoxycoformycin) : use of fludarabine in combination with pentostatin is not recommend