Pharmacologyfluticasone: a corticosteroid with anti-inflammatory activity, immunosuppressive properties, and antiproliferative actions.vilanterol: a long-acting beta2-agonist, relaxes bronchial smooth muscle by selective action on beta2-receptors with little effect on heart rate.use: labeled indicationsasthma: treatment of asthma in patients >=18 years.chronic obstructive pulmonary disease: maintenance treatment of airflow obstruction in patients with chronic obstructive pulmonary disease (copd), including chronic bronchitis and/or emphysema- to reduce exacerbations of copd in patients with a history of exacerbations.fluticasone 100 mcg/vilanterol 25 mcg is the only strength indicated for the treatment of copd.limitations of use: not indicated for the relief of acute bronchospasm.