Bepotastine is a non-sedating, selective antagonist of the histamine 1 (h1) receptor. bepotastine was approved in japan for use in the treatment of allergic rhinitis and uriticaria/puritus . it is available in oral and opthalmic dosage forms in japan.bepotastine is a non-sedating, selective antagonist of the histamine 1 (h1) receptor. it belongs to the second-generation piperidine chemical class. it is a mast cell stabilizer and suppresses the migration of eosinophils into inflamed tissues. furthermore, bepotastine does not interact with serotonin, muscarinic, benzodiazepine, and beta-adrenergic receptor that would otherwise result in adverse reactions such as dry mouth or sonmolence.onset of action = 0.25 hours- duration of action = 12-24 hours