About clomiphenesa selective estrogen receptor modulator (serm),chlorotrianisene derivative, ovulation stimulator ,fertility agent.ssmechanism of action of clomiphenesthe drug is an estrogen antagonist which exerts it`s pharmacological action by inducing ovulation. it induces gonadotropin secretion in women by blocking estrogenic feedback inhibition of pituitary. it increases the amount of lh and fsh released at each secretary pulse which results in enlargement of ovaries and ovulation. sin men increased gonadotropin levels results in increased steroidogenesis and helps in oligospermia and infertility. ssindications for clomiphenes1. anovulatory infertility s2. oligomenorrhoea s3. post pill amenorrhoea s4. oligospermia s5. polycystic ovary syndrome s6. lactation amenorrhoea. s7. psychogenic amenorrhoea s8. menorrhagia due to hyper plastic endometrium.