About cinchocainean amide derivative, most potent and toxic long-acting local anesthetics, a local anaestheticmechanism of action of cinchocainecinchocaine is a local anesthetic. it works by blocking the pathway of pain signals along nerves. it inhibits conduction of nerve impulses and decreases cell membrane permeability to ions at the site of the pain. this prevents an electrical signal building up and passing along the nerve fibres to the brain. in this way cinchocaine causes about hydrocortisone topicaltopical synthetic glucocorticoid, anti-inflammatory and anti-pruritic.mechanism of action of hydrocortisone topicalthe drug exerts it`s pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. this structural change allows it`s migration in to the nucleus and then binding to specific sites on the dna which leads to transcription of specific m-rna and which ultimately regulates protein