It is indicated for the treatment of osteoporosis in postmenopausal women. in postmenopausal women, it increases bone mass and reduces the incidence of fractures, including those of the hip and spine (vertebral compression fractures).alendronate sodium is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption. bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone.cholecalciferol (vitamin d3) is a secosterol that is the natural precursor of the calcium-regulating hormone calcitriol (1,25 dihydroxyvitamin d3).stop using alendronate and cholecalciferol and call your doctor at once if you have a serious side effect such as:chest pain-difficulty or pain when swallowing-pain or burning under the ribs or in the back-new or worsening heartburn-severe joint, bone, or muscle pain-new or unusual pain in your thigh or hip- orjaw pain, numbness,...