About insulin lispropancreatic hormone, a fast acting insulin analogue, antidiabetic agent.mechanism of action of insulin lisproit is a fast acting insulin analogue. insulin acts through binding to a subunit of insulin receptors located on the cell membrane of all cells (highest densities are seen in muscle, liver, and adipose tissue).this binding induces aggregation and internalization of the receptor along with the bound insulin. this activates tyrosine kinase activity of the ? subunits and tyrosine residues of the ? subunits get autophosphorylated- thus the activity of this subunit to phosphorylate tyrosine residues of insulin receptor substrate proteins (irs1, irs2) is increased. these results in a cascade of phosphorylation and dephosphorylation reactions which lead to stimulation or inhibition of enzymes involved in the metabolic actions of insulin. action of insulin on metabolic enzymes are also mediated through second messengers like phosphatidyl inositol glycan (pig) and