Site and mode of action hyaluronidase has a temporary and reversible depolymerizing action on the polysaccharide hyaluronic acid which is present in the intercellular matrix of connective tissue. the intercellular "cement" is thereby made more permeable, permitting the rapid dispersal and absorption of injected substances- the reduction of tissue tension- and the rapid dispersal of extravascular fluid in joint and tissue damage. indications hypodermoclysis obstetric anaesthesia prevention of post-partum haemorrhage (with ergometrine) as an aid to local anaesthesia in ophthalmology as an aid to local anaesthesia in fracture reduction subcutaneous administration of radiopaque substances in pyelography contraindications hypersensitivity to hyaluronidase. not to be used to reduce the swelling of bites or stings or at sites where infection or malignancy is present.