About rofecoxibnsaid,selective cox-2 inhibitor, analgesic ,anti-inflammatory.mechanism of action of rofecoxibrofecoxib inhibits prostaglandin synthesis by inhibiting cox2 enzyme. this nsaid inhibit cox2 enzyme selectively (cox-2 is only produced in response to tissue injury and causes tissue inflammation, and thus pain. it works converting arachidonic acid into a specific prostaglandin which communicates the need for inflammation to the surrounding tissue). this results the anti-inflammatory actionindications for rofecoxib1. dysmenorrhea (pain with your menstrual period) 2. osteoarthritis