About mometasonea glucocorticoid steroid, anti psoriatic,anti asthma ,anti inflammatory.mechanism of action of mometasonemometasone is a topical medium potency glucocorticoid. the drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. this structural change allows it`s migration in to the nucleus and then binding to specific sites on the dna which leads to transcription of specific m-rna and which ultimately regulates protein synthesis. it exerts highly selective glucocorticoid action. it stimulates the enzymes needed to decrease the inflammatory response. the drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase a2 and thus decreases the production of prostaglandins, leukotrienes (lt), and platelet activating factor,