About loxapinea dibenzazepine derivative, a typical antipsychotic.mechanism of action of loxapineloxapine produce its antipsychotic activity by blocking the post synaptic receptor in the cns.indications for loxapinepsychosesinteractions for loxapinealcohol & other cns depressants: additive cns depression. tcas & antiparkinsonism drugs: anticholinergic effects potentiated. clonidine & methyldopa: hypotensive effect of these drugs inhibited. maois: orthostatic hypotension with maois.