Pharmacologyprecise mechanism of action is unknown- however, lacosamide selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing.indications and usageoraladjunctive treatment of partial-onset seizures.parenteraladjunctive treatment of partial-onset seizures when oral route is not feasible.dosage and administrationpartial-onset seizuresadults and children 17 y of age and olderpo/iv start with 50 mg twice daily. the dosage may be increased by 50 mg twice daily at weekly intervals up to the recommended maintenance dosage of 200 to 400 mg/day, based on response and tolerability.hepatic function impairmentadults and children 17 y of age and olderpo/iv titrate the dose with caution. max dosage of 300 mg/day is recommended in patients with mild or moderate hepatic impairment. not recommended in patients with severe hepatic impairm