It is indicated for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.dosage & administrationinitially, take two delayed-release tablets orally at bedtime (day 1). if this dose adequately controls symptoms the next day, continue taking two tablets daily at bedtime. however, if symptoms persist into the afternoon of day 2, take the usual dose of two tablets at bedtime that night then take three tablets starting on day 3 (one tablet in the morning and two tablets at bedtime). if these three tablets adequately control symptoms on day 4, continue taking three tablets daily. otherwise take four tablets starting on day 4 (one tablet in the morning, one tablet mid-afternoon and two tablets at bedtime).the maximum recommended dose is four tablets (one in the morning, one in the mid-afternoon and two at bedtime) daily.take on an empty stomach with a glass of water. swallow tablets whole. do not crush, chew, or split tablets.