About nebivololsthird generation cardio selective beta-1 receptor antagonist, antihypertensive.smechanism of action of nebivololsnebivolol is a 3rd generation cardio selective beta-1 receptor antagonist which reduces vascular resistance, acutely lowers arterial blood pressure without depressing left ventricular function and exerts anti hypertensive effects. the drug causes coronary vasodilatation and improves myocardial ischaemia through nitric oxide release.sindications for nebivolols1.hypertensionstypical dosage for nebivolols5mg once daily spatients above 65years of age: starts with 2.5mg and increases to 5mg based on patient`s response srenal impairment: starts with 2.5mg and increases to 5mg based on patient`s response