Properties:
Lansoprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles,it is a proton pump inhibitor it suppress the gastric acid secretion by the inhibition of the (H+,K+) ATPase enzymes system at the secretory surface of the gastric parietal cell. it blocks the final step of acid production.
This effect is dose related and leads to inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus.
The absorption of Lansoprazole is rapid so no significant effect of food on absorption if the drug is taken before meals.
Lansoprazole is 97% bound to the plasma proteins. It is extensively metabolites in liver.
The acid inhibitory effect of Lansoprazole last for 24 hours.