About cefotaximethird generation cephalosporin parenteral antibiotic.mechanism of action of cefotaximecefotaxime is a 3rd generation cephalosporin which exerts its bactericidal action against both gram positive & aerobic gram negative organisms by inhibiting bacterial cell wall synthesis. cefotaxime inhibits transpeptidase & thus prevents cross linking of bacterial cell wall. transpeptidase & associated proteins constitute various types of specific binding proteins which have affinity for cephalosporins like cefotaximessindications for cefotaximes1.meningitis s2.resistant hospital acquired infections s3.septicemia s4.infections in immunocompromised patients s5.urinary tract &genital tract infections s6.surgical prophylaxis s7.skin & soft tissue infections s8.bone & joint infections s9.gonorrhea. ssinteractions for cefotaximessynergy with aminoglycosides.