About metoclopramidesit is a dopamine antagonist - antiemetic gastroprokinetic agent.smechanism of action of metoclopramidesmetoclopramide acts through both serotonergic and dopaminergic receptors. metoclopramide binds to serotonin (5 ht3 &5ht4) and dopamine (d2) receptor. santiemetic action: metoclopramide inhibits dopamine receptor in the chemoreceptor trigger zone and produces antiemetic action. sintestinal motility modifying action: the binding of metoclopramide on 5ht4 receptor will activate interneuron and enhance the release of acetylcholine innervating the smooth muscles. this produces gastric emptying and enhances lower esophageal sphincter tone. smigraine: metoclopramide is used in migraine to relieve nausea and vomiting sanaesthetic adjuncts: it is used preoperatively in order to reduce the post operative vomiting.