Sinopril, (lisinopril), lysine analogue of enalaprilat, is a peptidyl dipeptidase inhibitor. It inhibits the angiotensin-converting enzyme (ACE) that catalyses the conversion of angiotensin I to the vasoconstrictor peptide, angiotensin II.Sinopril, (lisinopril), is indicated as:-Treatment of hypertension, either alone as initial therapy or concomitantly with other classes of antihypertensive agents.-Adjunctive therapy in the management of heart failure in patients who are not responding adequately to diuretics and digitalis.-Treatment of hemodynamically stable patients within 24 hours of acute myocardial infarction, to improve survival.


About lisinoprilsdicarboxylate-containing angiotensin-converting enzyme (ace) inhibitor, antihypertensive.smechanism of action of lisinoprilsit is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. it decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in bp. the arterioles dilate and the compliance of larger arteries is increased. both systolic and diastolic bp is lowered. it has no effect on cardiac output and cardiovascular reflexes. there is little dilatation of capacitance vessels- so postural hypotension is not a problem. the drug does not compromise renal, cerebral, and coronary blood flow. bp lowering depending up on sodium status and renin angiotensin activity. so greater fall in bp occurs in reno vascular accelerated and malignant hypertension.