Gridamom exhibits marked anti-inflammatory activity and marked anti-psoriatic activity,indicated for the treatment of inflammatory and pruritic manifestations of psoriasis (excluding widespread plaque psoriasis) and atopic dermatitis.


About mometasonea glucocorticoid steroid, anti psoriatic,anti asthma ,anti inflammatory.mechanism of action of mometasonemometasone is a topical medium potency glucocorticoid. the drug exerts its pharmacological action by penetrating and binding to cytoplasmic receptor protein and causes a structural change in steroid receptor complex. this structural change allows it`s migration in to the nucleus and then binding to specific sites on the dna which leads to transcription of specific m-rna and which ultimately regulates protein synthesis. it exerts highly selective glucocorticoid action. it stimulates the enzymes needed to decrease the inflammatory response. the drug exerts anti-inflammatory and immunosuppressant actions as follows: - 1) induce lipocortins in macrophages, endothelium, and fibroblasts which inhibits phospholipase a2 and thus decreases the production of prostaglandins, leukotrienes (lt), and platelet activating factor,