About bupropionnorepinephrine and dopamine reuptake inhibitor,nicotinic antagonist, aminoketone derivative, atypical antidepressant, smoking cessation aid.mechanism of action of bupropionbupropion blocks the re-uptake of neurotransmitter dopamine and noradrenaline from the synapse in to the presynaptic nerve terminal in the cns. it has only a less activity in blocking the reuptake of serotonin. bupropion potentiates the noradrenergic and dopaminergic activity and produces antidepressant activity. smoking cessation action: bupropion is a competitive antagonist of nicotine. indications for bupropion1. depression 2. smoking cessation treatment