Composition

Each Hard Gelatin Capsule contains:
Doxycycline (as hyclate) ..................................................................................
100 mg
Inactive ingredients: Microcrystalline cellulose, maize starch, sodium lauryl sulphate, colloidal silicon dioxide (Aerosil 200), magnesium stearate

Dosage and Administration

The capsules should be swallowed with plenty of fluid in either the resting or standing position and well before going to bed for the night to reduce the likelihood of oesophageal irritation and ulceration.

If gastric irritation occurs, it is recommended that Doxydox Capsules be given with food or milk.

Adults:
The usual dose of Doxydox Capsules for the treatment of acute infections is 200 mg on the first day (administered as a single dose or divided into two equal doses with a twelve hour interval), followed by a maintenance dose of 100 mg/day.

In the management of more severe infections (particularly chronic infections of the urinary tract), 200 mg daily should be given throughout the treatment period.

Exceeding the recommended dosage may result in an increased incidence of side effects.

Therapy should be continued at least 24-48 hours after symptoms and fever have subsided.

When used in streptococcal infections, therapy should be continued for 10 days to prevent the development of rheumatic fever or glomerulonephritis.

Specific Infections:
Acne vulgaris: 100 mg every other day in the morning with breakfast, for up to 12 weeks.

Sexually transmitted diseases: 100 mg twice daily for 7 days is recommended in the following infections: uncomplicated gonococcal infections (except anorectal infections in men); uncomplicated urethral, endocervical or rectal infection caused by Chlamydia trachomatis; non-gonococcal urethritis caused by Ureaplasma urealyticum.

Acute epididymo-orchitis caused by Chlamydia trachomatis or Neisseria gonorrhoeae: 100 mg twice daily for 10 days.

Primary and secondary syphilis: 300 mg a day in divided doses for at least 10 days.

Louse-borne and tick-borne relapsing fevers: A single dose of 100 mg or 200 mg according to severity.

Chloroquine-resistant falciparum malaria: 200 mg daily for at least 7 days.
Due to the potential severity of the infection, a rapid-acting schizonticide such as quinine should always be given in conjunction with doxycycline; quinine dosage recommendations vary in different areas.

For the prevention of scrub typhus: 200 mg as a single dose.

For the prevention of travellers' diarrhoea in adults: 200 mg on the first day of travel (administered as a single dose or as 100 mg every 12 hours) followed by 100 mg daily throughout the stay in the area.
Data on the use of the drug prophylactically is not available beyond 21 days.

For the prevention of leptospirosis: 200 mg once each week throughout the stay in the area and 200 mg at the completion of the trip.
Data on the use of the drug prophylactically are not available beyond 21 days.

Children: Not recommended.

Elderly: Doxydox may be prescribed in the usual dose with no special precautions.
No dosage adjustment is necessary in the presence of renal impairment.

Renal impairment: Administration of doxycycline at the usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal impairment.

The anti-anabolic action of the tetracyclines may cause an increase in blood urea, but this does not occur with the use of doxycycline in patients with impaired renal function.

Haemodialysis does not alter the serum half-life of doxycycline