Prucalopride is a drug acting as a selective, high affinity 5-ht4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalizing bowel movements.prucalopride, a first in class dihydro-benzofuran-carboxamide, is a selective, high affinity serotonin (5-ht4) receptor agonist with enterokinetic activities. prucalopride alters colonic motility patterns via serotonin 5-ht4 receptor stimulation: it stimulates colonic mass movements, which provide the main propulsive force for defecation.