About mesalazines5-aminosalicylic acid derivative, anti-inflammatory bowel agent.ssmechanism of action of mesalazinesmesalazine exerts its anti-inflammatory action by inhibiting lipoxygenase enzyme. this will leads to decreased production of pro-inflammatory leukotrienes (ltb4) and 5-hydroxy eicosa tetra enoic acids (hete) in the intestinal wall. it inhibits the production of inflammatory mediators like interleukin-1, tumor necrosis factor-alpha etc. ssindications for mesalazines1.ulcerative colitis s2.crohn`s disease s3.proctitis and proctosigmoiditis (use only suppositories)