Entecavirnucleoside analog, reverse transcriptase inhibitor, oral antiviral drug used in the treatment of hepatitis b infection.mechanism of action of entecavirby competing with the natural substrate deoxyguanosine triphosphate, entecavir functionally inhibits all three activities of the hbv polymerase (reverse transcriptase, rt): (1) base priming, (2) reverse transcription of the negative strand from the pregenomic messenger rna, and (3) synthesis of the positive strand of hbv dna.
upon activation by kinases, the drug can be incorporated into the dna which has the ultimate effect of inhibiting the hbv polymerase activity.indications for entecavirfor the treatment of chronic hepatitis b virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (alt or ast) or histologically active disease.