About paracetamolsacetanilide derivative, non narcotic analgesic,antipyretic.smechanism of action of paracetamolsparacetamol has analgesic and antipyretic action. sit is more active on cyclo-oxygenase enzyme in brain. peripherally it is a poor inhibitor of prostaglandin synthesis. sanalgesic action: paracetamol raises the pain threshold and produces analgesic effect. santipyretic action: paracetamol lowers fever by direct action on the thermoregulatory centre in the hypothalamus and block the effects of endogenous pyrogen. sindications for paracetamols1. to relieve pain and fever s2. acute gout s3. migraine sinteractions for paracetamolscholestyramine: reduces absorption of paracetamol. scharcoal: activated, administered immediately reduces absorption of paracetamol. sdomperidone and metochlopramide: enhance absorption of paracetamol. salcohol: chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol. s