About ebastinesecond generation, long-acting and selective h1 antagonist, non-sedative antihistamine.mechanism of action of ebastinedrug and its active metabolite is selective peripheral histamine h1 receptor antagonist. thus it prevents the attachment of histamine on receptors and its activation (activation of receptors of histamine on various tissues produce various allergic symptoms e.g. runny nose).ebastine also has a specific inhibitory effect on th2-type cytokine production and inhibit t cell migration and pro-inflammatory cytokine production by t cells and macrophagesindications for ebastine1. seasonal and perennial allergic rhinitis 2. idiopathic chronic urticaria 3. t cell-mediated allergic inflammatory disorders (asthma, atopic dermatitis) 4. th2 -type autoimmune diseases